MacGyver reluctantly traveled to Kambezi in Africa to search for Billy Colton, the youngest of the bounty hunting Colton brothers, when he stopped showing up for work at the Phoenix Foundation. A search of Billy’s locker found a case file for a wanted animal poacher which Billy’s brothers had failed to catch 2 years earlier called Ladysmith. Pete surmised that Billy had gone to catch Ladysmith himself to prove that he was ready to join the bounty hunting business.
In the process of tracking down Billy, MacGyver came face to face with the issues involved in the fight against animal poaching and it’s disastrous affects.
Kambezi is a fictitious county which appears from the map shown in the episode to be situated on the west coast of Africa.